(Structured PhD) Pharmacology and Therapeutics

College of Medicine, Nursing, & Health Sciences,
School of Medicine

Course overview

Discipline overview
The Pharmacology Discipline is actively engaged in a vigorous research programme which is centred around the areas of neuropharmacology (the study of the effects of drugs on the central nervous system), immunopharmacology (the study of the effects of drugs on the immune system), and signalling in vertebrate development.

The Discipline has research links with other national and international centres, including Biochemistry, Anatomy, Physiology, the National Centre for Biomedical Engineering Science, the Regenerative Medicine Institute, and the Network of Excellence for Functional Biomaterials at NUI Galway, Trinity College Dublin, the University of Nottingham, University College London, Cardiff University, Lund University, Universidad Complutense de Madrid, the University of Pennsylvania, and H/S Lundbeck, Denmark. The research activities of the Discipline are funded from a variety of competitive sources.

Programmes available

Structured PhD (full-time, four years)

Entry requirements

Candidates should normally have a high honours standard in a relevant academic discipline at primary degree level or equivalent, together with the support of an academic staff member who is approved by the College to supervise the research in terms of its nature and scope.

Additional entry requirements
Candidates may be required to submit a research proposal for consideration by the School as part of their application.

Areas of interest

  • Molecular and cellular biology of vertebrate embryo development
  • Antidepressants; novel targets; modulating immune responses
  • Non-animal alternatives for toxicological assessment of drugs
  • Novel cell, gene and pharmacological therapies for Parkinson's disease
  • Molecular mechanisms of intestinal injury, repair and carcinogenesis; inflammatory bowel disease, colon cancer and radiation injury to the intestinal tract
  • Caspases, cell death and differentiation;, chemotherapy-induced apoptosis and cancer
  • Neurochemical, neuroendocrine and molecular mechanisms underlying pain, anxiety and depression
  • Neuropharmacology of cannabinoid and opioid receptors; The endocannabinoid system in pain, anxiety, Parkinson’s disease and neuroimmune function
  • Toll-like receptors and the brain-gut axis

Researcher profiles

Prof. Laurence Egan
laurence.egan@nuigalway.ie
RESEARCH INTERESTS:
Molecular mechanisms of intestinal injury, repair and carcinogenesis; focus on biological functions of transcription factor NF-kappaB; identification and characterization of novel therapeutic targets for inflammatory bowel disease, colon cancer and radiation injury to the intestinal tract.

Dr. John Kelly
john.kelly@nuigalway.ie
RESEARCH INTERESTS:
Investigation of the mechanism of action of antidepressants and the development of novel targets using animal models; the effects of antidepressants on modulating immune responses; development of non-animal alternatives for toxicological assessment of drugs.

Dr. Maura Grealy
maura.grealynuigalway.ie
RESEARCH INTERESTS:
Developmental biology using the zebrafish as a model for cardiovascular development and disease; the role of signalling, via cell-cell adhesion molecules, in heart development; effects of neuroactive drugs on embryo development.

Dr. David Finn
david.finn@nuigalway.ie
RESEARCH INTERESTS:
Neurochemical, neuroendocrine and molecular mechanisms underlying pain, anxiety and depression; neuropharmacology of cannabinoid and opioid receptors; imidazoline binding sites, brain monoamines and the stress response; neuroimmune mechanisms of relevance to pain, inflammation and mood disorders.

Dr. Eilís Dowd
eilis.dowd@nuigalway.ie
RESEARCH INTERESTS:
Development and functional validation of novel therapies for Parkinson’s disease including novel pharmacological, gene, and cell therapies.

Dr. Howard Fearnhead
howard.fearnhead@nuigalway.ie
RESEARCH INTERESTS:
The role of caspases in apoptosis and cellular differentiation, investigating how caspases are activated, the downstream effects of activation and the consequences of a failure of the apoptotic program; a particular focus is the role of apoptosis and caspases in cancer chemotherapy.

Dr. Declan McKernan
Declan.mckernan@nuigalway.ie
RESEARCH INTERESTS:
The role of Toll-like receptors in brain-gut signalling particularly in visceral hypersensitivity, the effects of stress on intestinal inflammation with focus on TLR expression/activity in distinct regions of the gut as well as the role of Toll-like receptors in psychiatric disorders such as schizophrenia and depression.

Find out more

Ms. Una Ryan
T +353 91 492 246
una.ryan@nuigalway.ie

PAC code

Structured PhD, full-time—GYP11 - College of MNHS
Structured PhD, full-time-GYR16 - College of Science

Current project

Fees for this course

Learn more

Postgraduate videos

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(Structured PhD) Physiology

College of Medicine, Nursing, & Health Sciences,
School of Medicine

Course overview

The Discipline carries out research in a number of areas including the disorders of the central nervous system, electrophysiology, ovarian physiology, skeletal muscle physiology, diabetes mellitus and liver regeneration.

Programmes available

Structured PhD (full-time, four years)

Entry requirements

Candidates should normally have a high honours standard in a relevant academic discipline at primary degree level or equivalent together with the support of an academic staff member who is approved by the College to supervise the research in terms of its nature and scope.

Additional entry requirements
Candidates may be required to submit a research proposal for consideration by the School as part of their application.

Areas of interest

• Neurotoxicity, neurodegeneration and neuroprotection
• Reproductive physiology
• Liver microcirculation and regeneration
• Skeletal muscle plasticity and muscular dystrophy
• Epithelial physiology and electrophysiology
• Neuroinflammation, mood disorders and pain
• Gastric function; Diabetes Mellitus

Researcher profiles

Dr. Karen Doyle
karen.doyle@nuigalway.ie
www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Karen
RESEARCH INTERESTS:
Neurotoxicity; neurodegeneration; cell stress and neuroprotection; Neurological and psychiatric disorders of the central nervous system

Dr. Ailish Hynes
ailish.hynes@nuigalway.ie
www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Ailish
RESEARCH INTERESTS:
Reproductive physiology; follicle growth and development; ovulation control; preimplantation embryo growth and development.

Dr. Beth Mallard
beth.mallard@nuigalway.ie
www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Beth
RESEARCH INTERESTS:
Liver microcirculation; intravital fluorescence microscopy; liver regeneration.

Dr. Karl McCullagh
Karl.mccullagh@nuigalway.ie
www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Karl
RESEARCH INTERESTS:
Skeletal muscle biology from basic cellular mechanisms to disease states such as muscular dystrophy; gene and stem cell therapy for muscular and neuromuscular disorders.

Dr. Leo Quinlan
leo.quinlan@nuigalway.ie
www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Leo
RESEARCH INTERESTS:
Epithelial physiology (inflammation and dyregulation in oviduct, colon and bladder), Stem cells, neuronal noise (neuro-modulation), electrophysiology (Ussing chambers, patch clamp, brain slice), Cell signalling (inositol, purinoceptors)

Dr. Michelle Roche
Michelle.roche@nuigalway.ie
www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Michelle
RESEARCH INTERESTS:
My research interests focus on increasing understanding of the neurobiological mechanisms underpinning neuroinflammation, mood disorders (anxiety and depression) and pain.

Dr. Amir Shafat
amir.shafat@nuigalway.ie
http://www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Amir
RESEARCH INTERESTS:
Nutritional regulation of gastric emptying rates; Glucose oxidation test as a biomarker for type 2 diabetes mellitus; Stable isotope techniques e.g. 13CO2 breath test.

Prof. Antony Wheatley
antony.wheatley@nuigalway.ie
http://www.nuigalway.ie/faculties_departments/physiology/StaffMain.html#Tony
RESEARCH INTERESTS:
(i) intravital fluorescence microscopy for investigation of the microcirculation of the organs/tissues; (ii) liver regeneration (iii) immune-mediated liver injury (iv) gut permeability


PAC code

Structured PhD, full-time—GYP12 - College of MNHS
Structured PhD, full-time-GYR15 - College of Science

Current project

Fees for this course

Learn more

Postgraduate videos

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